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Nebulized budesonide, or dexamethasone given either orally or intramuscularly, were effective in treating croup.
With regard to the inhalation of drugs, it has been observed that up to 75% of patients do not use a successful inhalation technique [13,14].
The pharmacokinetics of prednisone and prednisolone is nonlinear due to a variable protein binding.
Only free prednisolone is able to pass cell membranes and therefore able to cause a pharmacological effect .
Grade 2: stridor at rest, starting dyspnea, slight jugular stricture.
Grade 3: dyspnea at rest, pronounced thoracic strictures, paleness, tachycardia 160/min.
Good evidence now exists to support routine corticosteroid therapy in all children with croup .
Glucocorticoids alleviate respiratory distress due to the inflammation of the larynx and are therefore drugs of choice for croup .
Comparison of prednisolone with dexamethasone demonstrated similar efficacy but for dexamethasone, no rectal dosage form is available [6,9].